White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). WMH tend to show a peri-basal ganglia pattern in HA, whereas a multiple subcortical spots pattern can be observed in CAA. Periventricular WMH (PVWMH) have been reported to be posterior predominant using a semiautomated segmentation method and logarithmic transformation, not used in daily clinical practice. In these studies including CAA patients, patients initially presented with haemorrhage-related symptoms. In another study analysing PVWMH and cerebral amyloid evidence in patients with mild cognitive impairment, frontal PVWMH burden was associated with high uptake on florbetapir-PET whereas parietal and occipital PVWMH burden was associated with low CSF-amyloid-beta. The aim of this study is the descriptive comparative analysis of the distribution of PVWMH between CAA and HA patients with radiological tools available in daily practice.
Age range
18 Years
Sex
ALL
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Distribution of PVWMH
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Distribution of PVWMH - total PVWMH extent.
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Corpus callosum (CC) WMH
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Corpus callosum (CC) WMH - total CC-PVWMH extent.
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Ratios
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Anterior PVWMH
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Posterior PVWMH
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Total PVWMH
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Posterior/anterior PVWMH ratio
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anterior CC-PVWMH
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Posterior CC-PVWMH
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Total PVWMH and posterior/anterior CC-PVWMH ratio
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