White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). WMH tend to show a peri-basal ganglia pattern in HA, whereas a multiple subcortical spots pattern can be observed in CAA. Periventricular WMH (PVWMH) have been reported to be posterior predominant using a semiautomated segmentation method and logarithmic transformation, not used in daily clinical practice. In these studies including CAA patients, patients initially presented with haemorrhage-related symptoms. In another study analysing PVWMH and cerebral amyloid evidence in patients with mild cognitive impairment, frontal PVWMH burden was associated with high uptake on florbetapir-PET whereas parietal and occipital PVWMH burden was associated with low CSF-amyloid-beta. The aim of this study is the descriptive comparative analysis of the distribution of PVWMH between CAA and HA patients with radiological tools available in daily practice.
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Distribution of PVWMH
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Distribution of PVWMH - total PVWMH extent.
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Corpus callosum (CC) WMH
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Corpus callosum (CC) WMH - total CC-PVWMH extent.
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Ratios
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Anterior PVWMH
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Posterior PVWMH
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Total PVWMH
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Posterior/anterior PVWMH ratio
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anterior CC-PVWMH
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Posterior CC-PVWMH
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Total PVWMH and posterior/anterior CC-PVWMH ratio
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