WithdrawnNot Applicable

CPX in Paradoxical Low Flow Aortic Stenosis

Stopped: Inability to execute internal logistics to begin enrollment

United States0Started 2017-09-30

Plain-language summary

Severe aortic stenosis is a condition with poor life expectancy once it becomes symptomatic. There are no prospective studies illustrating the utility of cardiopulmonary stress (CPX) testing in diagnosing and prognosticating patients with paradoxically low gradient and low flow severe aortic stenosis. We aim to prospectively investigate the utility of CPX in this patient population with the hypothesis that utilizing CPX parameters would better identify higher risk patients warranting further evaluation and possibly intervention sooner.

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aortic valve area \<1 cm2 * Mean aortic pressure gradient \<40 mmHg, * Left ventricular ejection fraction \>50% by 2D transthoracic echocardiography Exclusion Criteria: * Ischemic heart disease * Severe mitral valve disease (regurgitation or stenosis) * Moderate or severe aortic regurgitation * Pulmonary hypertension (PA pressure \>50 mmHg) * COPD * Uncontrolled hypertension (Systolic BP or Diastolic BP greater than 150/90) * Inability or unwillingness to exercise.

What they're measuring

Functional status

Timeframe: August 30 2017-April 30 2017

Trial details

NCT IDNCT05481814

SponsorHenry Ford Health System

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-04-01

View on ClinicalTrials.gov More Aortic Valve Stenosis trials