CompletedNot Applicable

Nociplastic Pain in Patients With Chronic Shoulder Pain

Greece70 participantsStarted 2022-07-18

Plain-language summary

The aim of this study was to investigate predictors of nociplastic shoulder pain. Factors of psychological distress, functionality, fitness, quality of life, quality of sleep, functioning of the parasympathetic system, and lifestyle will be examined. Patients with nociplastic pain will be identified using the classification system proposed by the IASP.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients (men and women) with chronic shoulder pain (lasting more than 3 months, 3/10 Numeric Pain Rating Scale), * aged 18-65 years * mentally able to follow instructions or * healthy volunteers * aged 18-65 * who do not experience pain and have not received analgesic medication in the last trimester. Exclusion Criteria: * referred shoulder pain from different primary sources of pain (eg shoulder pain in women with mastectomy or stroke), * pain manifested by movements in the neck, * shoulder arthroplasty or fractures or dislocation of the shoulder, - * diagnosis of chronic pain syndrome such as fibromyalgia, chronic fatigue syndrome, chronic regional pain syndrome, cancer diagnosis, osteoporosis, rheumatic inflammatory diseases, * use of medication for neurological/psychiatric disorders, * the presence of gastrointestinal or renal disease * taking medication that may affect the assessment results, such as calcium channel blockers that could alter HRV, * pregnancy or childbirth before 1 year will be excluded from the study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Pressure Pain Threshold (PPT)

Timeframe: Only one time (baseline)

Conditioned Pain Modulation (CPM)

Timeframe: Only one time (baseline)

Nociplastic Pain Criteria

Timeframe: Only one time (baseline)

Trial details

NCT IDNCT05481710

SponsorParaskevi Bilika

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-01-10

View on ClinicalTrials.gov More Chronic Shoulder Pain trials

Plain-language summary

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.