Central Sodium Sensing: Implications for Blood Pressure Regulation (NCT05480722) | Clinical Trial Compass
CompletedNot Applicable
Central Sodium Sensing: Implications for Blood Pressure Regulation
United States29 participantsStarted 2022-06-01
Plain-language summary
The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pressure regulation, which has major public health implications.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age: 18 - 45 years
* Blood pressure: \>100/60 mmHg and \<130/80 mmHg
* BMI: 18.5 kg/m2 - 30 kg/m2
* Serum potassium: 3.5 mmol/L - 5.5 mmol/L
Exclusion Criteria:
* Age: \< 18 years or \> 45 years
* Blood pressure: \< 100/60 mmHg or \> 130/80 mmHg
* BMI: \< 18.5 kg/m2 or \> 30 kg/m2
* Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L
* Abnormal ECG
* History of - cardiovascular, cancer, metabolic, respiratory, renal disease
* Hormone replacement therapy
* Current tobacco or nicotine use
* Pregnant or nursing mothers
* Major brain injury (concussions do not count)
* Clinically diagnosed psychiatric or neurological disorder
* Clinically diagnosed anxiety or depression
* Psychiatric, neurological, anxiety or depression medications
* Hypertension medications
* Sulfonamide drug allergy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Functional Connectivity Between the Subfornical Organ and Organum Vasculosum of the Lamina Terminalis (Z-score)
Timeframe: Functional connectivity (FC) was calculated at baseline (~10 min). Then, participants received a 30-minute hypertonic saline infusion (HSI) with or without furosemide before. FC was calculated during the early (0-15 min) and late phase (15-30 min) of HSI.