UnknownPhase 2/3

COMPARATIVE ANALYSIS OF INNOVATIVE BONE HEALING TECHNIQUES

Pakistan60 participantsStarted 2020-12-17

Plain-language summary

the study intends to observe the outcome of interventions (concentrated growth factor with autograft and xenograft) used to expedite bone healing and adaptation with minimal side effects. Three different modalities are being used to bridge the mandibular fracture defects (\>5mm-\<5cm). Those modalities include group A- autograft, group B-autograft with concentrated growth factor, and group C- xenograft with concentrated growth factor. the outcomes are measured in terms of acquired bone density (Hounsfield unit) that is obtained at the 4th and 6th month post-operatively via cone-beam computed tomography.

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male/female * Mandible fracture (symphysis, parasymphysis, and body) * Defect gap of bone \>5mm and \<5cm. * Non-union fracture. (Fracture that does not heal after 8 weeks of treatment is known as a non-union) * Mal-union (when the fracture segments are not in anatomical alignment and heals in that way forming a bone between displaced segments) * Delayed union (Fracture which takes greater than 5 weeks to repair is a delayed union) Exclusion Criteria: * Systemic disease involvement such as diabetes mellitus. * Bone-related disorders such as osteoarthritis, * Undergoing Chemo and or radiotherapy * Gunshot trauma with more than 5cm bone defect * Fracture with open wounds

What they're measuring

bone density

Timeframe: 6 months

Trial details

NCT IDNCT05480631

SponsorDow University of Health Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-07-20

View on ClinicalTrials.gov More To Assess the Bone Healing in Fracture Mandible Defects trials