Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study (NCT05475158) | Clinical Trial Compass
CompletedNot Applicable
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
South Korea117 participantsStarted 2019-09-01
Plain-language summary
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not, using optical coherence tomography angiography (OCTA).
Who can participate
Age range
50 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Clinical and pathologic diagnosis of ADD or MCI as well as cognitively unimpaired control (CU) from the Neurologic Clinic of Pusan National University Hospital
Exclusion Criteria:
* Patient not within the ages of 50-90 years old
* Patient with glaucoma, macular degeneration, retinal vascular disease including diabetic retinopathy, retinal vein occlusion
* Intraocular pressure (IOP) ≥ 21 mmHg
* Dense corneal or ocular media opacity
* History of ocular trauma or associated ocular disease
* Astigmatism ≥ 3.0 diopter or spherical equivalent ≥ 6.0 diopter
* Best corrected visual acuity (BCVA) \< 20/40
* Any ocular surgery except uncomplicated cataract extraction
* Uncontrolled hypertension and diabetes
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
SD-OCT imaging
Timeframe: Through study completion, measured at enrollment and analyzed from September 2019 to July 2021
2
SD-OCTA imaging
Timeframe: Through study completion, measured at enrollment and analyzed from September 2019 to July 2021