CompletedNot Applicable

The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia

Egypt90 participantsStarted 2022-08-05

Plain-language summary

Optimal multimodal opioid-sparing analgesic technique is considered as one of the most important Enhanced recovery pathways (ERPs) or enhanced recovery after surgery (ERAS) interventions that mitigate the undesirable effects of surgical stress response. Implementation of ERP has been shown to reduce postoperative complications and shorten the hospital LOS.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 - 65 years * Ejection fraction (EF) \> 35% * Elective isolated CABG * Valve surgery, Atrial septal defect (ASD) closure * Cross clamp time ≤ 90 min * Cardiopulmonary bypass time ≤ 120 min. Exclusion Criteria: * Poor left ventricular function with intra-aortic balloon pump support * Recent myocardial infarction (last seven days) * Combined procedure (i.e., CABG + other heart/vascular procedure) * Emergency surgery, and Redo surgery,Hepatic or renal failure, creatinine \>1.5 -History of neurological disorders or convulsions

What they're measuring

The total postoperative fentanyl consumption (μg)

Timeframe: the first 48 hours postoperative

Trial details

NCT IDNCT05474183

SponsorFayoum University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05-10

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