Not Yet RecruitingNot Applicable

Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis

7,838 participantsStarted 2025-11

Plain-language summary

A prospective, individual patient data meta-analysis (IPDMA) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Participants of the ARISE FLUIDS, CLASSIC, CLOVERS \& EVIS trials who had: * Suspected or proven infection * Systolic blood pressure (SBP) \<100 mm Hg OR mean arterial pressure (MAP) \<65 mm Hg * Lactate ≥ 2.0 mmol/L * Requirement for vasopressors to meet perfusion targets Exclusion criteria: Participants not in the ARISE FLUIDS, CLASSIC, CLOVERS \& EVIS trials

What they're measuring

All-cause mortality at 90 days post randomisation

Timeframe: 90 days

Trial details

NCT IDNCT05453565

SponsorAustralian and New Zealand Intensive Care Research Centre

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-11

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