The aim of this longitudinal trial is to investigate the effects of a 10±3-day fasting period in 30 subjects. Changes in the oral and gut microbiota, halitosis, as well as inflammatory and antioxidative parameters and biomarkers of sulfur metabolism will be analysed.
Age range
18 Years – 80 Years
Sex
ALL
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Changes in halitosis
Timeframe: daily from baseline to the 3rd day of food reintroduction
Changes in microbiota compositions of subgingival microbial and plaque sampling
Timeframe: Baseline, fasting day 10, food reintroduction day 3
Changes in microbiota composition in saliva
Timeframe: Baseline, fasting day 10, food reintroduction day 3, 1 and 3 months afterwards
Changes in microbiota composition in faeces
Timeframe: Baseline, first spontaneous stool after food reintroduction (up to day 3), 1 and 3 months afterwards
Changes in total antioxidant capacity (TAC)
Timeframe: Baseline, fasting day 3, 5, 10
Changes in hydrogen sulfide production capacity
Timeframe: at the beginning and the end of fasting, on day 3 and 5, as well as at the food reintroduction