The aim of this longitudinal trial is to investigate the effects of a 10±3-day fasting period in 30 subjects. Changes in the oral and gut microbiota, halitosis, as well as inflammatory and antioxidative parameters and biomarkers of sulfur metabolism will be analysed.
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Changes in halitosis
Timeframe: daily from baseline to the 3rd day of food reintroduction
Changes in microbiota compositions of subgingival microbial and plaque sampling
Timeframe: Baseline, fasting day 10, food reintroduction day 3
Changes in microbiota composition in saliva
Timeframe: Baseline, fasting day 10, food reintroduction day 3, 1 and 3 months afterwards
Changes in microbiota composition in faeces
Timeframe: Baseline, first spontaneous stool after food reintroduction (up to day 3), 1 and 3 months afterwards
Changes in total antioxidant capacity (TAC)
Timeframe: Baseline, fasting day 3, 5, 10
Changes in hydrogen sulfide production capacity
Timeframe: at the beginning and the end of fasting, on day 3 and 5, as well as at the food reintroduction