A Prospective, Randomized, Controlled Clinical Study of BET Combined With Tympanostomy Tube Insertion in the Treatment of Intractable OME After Radiotherapy for NPC

Inclusion Criteria: * patients clinically diagnosed OME after radiotherapy for NPC (diagnostic criteria: have fluid drained from tympanic cavity during tympanocentesis) , who had completed radiotherapy for ≥6 months, and had failed to respond after two or more times of tympanocentesis * Eustachian Tube Dysfunction Questionnaire score greater than 14 * clinical findings of a retracted drum * fluid behind the drum * tympanometry type B or C results * patients volunteered to participate in the study and signed the informed consent * patients volunteered to bear the corresponding costs of surgery and consumables. Exclusion Criteria: * NPC recurrence or other malignant tumor after radiotherapy * a perforated tympanic membrane * the presence of a ventilation tube * a period of less than six months following the final radiotherapy treatment * clear diagnosis of Eustachian ostium atresia or nasal obstruction diseases, such as severe deviated nasal septum, nasal polyp, choanal atresia, osteoradionecrosis of skull base after radiotherapy, etc. * patients with severe underlying diseases could not tolerate general anesthesia * patients who could not cooperate (including poor hearing and radiation encephalopathy) * patients with other middle ear diseases, such as middle ear cholesteatoma, osteoradionecrosis of temporal bone after radiotherapy, etc. * severe deglutition disorders * cleft palate