RecruitingPhase 2

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

United States75 participantsStarted 2023-04-20

Plain-language summary

This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.

Who can participate

Age range55 Years

SexALL

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Inclusion criteria

✓. Active diagnosis of amnestic mild cognitive impairment
✓. Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample
✓. Female and male subjects
✓. All races/ethnicities
✓. Age 55 years and older
✓. Fluent in English

Exclusion criteria

✕. Mild traumatic brain injury within past year
✕. Lifetime history of moderate or severe brain injury
✕. Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)
✕. Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)
✕. Current substance use disorder
✕. Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)
✕. Current vision or hearing impairment that interferes with testing
✕. Any electronic and or metallic implants in the skull or brain

What they're measuring

Changes in Rey Auditory Verbal Learning Test Score

Timeframe: Baseline and immediately after completion of each HD-tDCS condition

Trial details

NCT IDNCT05446584

SponsorUniversity of Texas Southwestern Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-05-01

Contact for this trial

Hannah Cabrera, MCRC

214-865-9508 Hannah.Cabrera@utsw.edu

View on ClinicalTrials.gov More Mild Cognitive Impairment trials