Serum Levels of Otolin-1 and Vitamin D in Pre- and Post-treatments of BPPV (NCT05446506) | Clinical Trial Compass
CompletedNot Applicable
Serum Levels of Otolin-1 and Vitamin D in Pre- and Post-treatments of BPPV
Thailand21 participantsStarted 2021-01-13
Plain-language summary
BPPV is the most common cause of vertigo. The pathophysiology of BPPV has not been cleared, several studies show that symptoms are caused by the displacement of otoconia from the macula of the utricle into the semicircular canals. These calcium carbonate particles then stimulate non-physiological movement of the endolymph leading to a false sensation of angular acceleration.
Biomarkers represent measurable products of biological processes, thus making an assessment of those processes more practical. Biomarkers in circulation are powerful indicators of normal and pathological biological processes, as well as, responses to pharmacological treatments. The inner ear-inclusive protein that has been published included Otolin-1, Otoconin-90/95, Prestin, Otoancorin, Otogelin, α-tectorin, β-tectorin and Cochlin.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Age 18 - 80 years
✓. History of brief episodes of positioning vertigo
✓. Positive positioning test; either Dix-Hallpike test or supine roll test in one or both ears
✓. First diagnosis of BPPV or recurrent BPPV
Exclusion criteria
✕. Clinical symptoms or sign of other central or peripheral vestibular disorder
✕. Previous history of balance disorders (for controlled group) or Previous history of balance disorders except BPPV (for BPPV group)
✕. Active infection
✕. Active cancer disease
✕. Conditions that may affect the level of otolin-1 such as previous mastoidectomy
✕. Conditions that may affect the level of vitamin D such as cardiovascular disease, diabetes mellitus type2, chronic liver disease, osteoporosis osteomalacia and active symptoms of migraine
✕. Major health conditions; except common chronic conditions e.g. hypertension, hypothyroidism, hypercholesterolemia, and reflux
✕. Major systemic illness, were undergoing active cancer treatment, took prednisone above 10 mg daily, took other immunosuppressive drugs, took any medications for rheumatoid arthritis other than NSAIDs, or had received antibiotics in the previous 6 months