Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain

Inclusion Criteria: * Demonstrated willingness to participate in the study and adhere to procedures by signing a written informed consent * Biological males aged 19-50 * Successful Physical Activity Readiness Questionnaire (PAR-Q) * Ability to swallow core temperature capsule * VO2Max \>35 mL/kg/min * No allergy or current dosage of H1 histamine receptor antagonists * Participants must be in good health with no 'Category A' diseases/conditions outlined in National Fire Protection Association (NFPA) 1582 (https://www.iafc.org/docs/default-source/1vcos/vws\_rrkit\_nfpa-1582.pdf?sfvrsn=ca9b9f0d\_2) Exclusion Criteria: * Biological females * Males below age of 19, and 51-years or older * Unsuccessful PAR-Q * VO2Max below 35 mL/kg/min * Allergy to H1 histamine receptor antagonists * Esophageal constriction (inability to swallow core temperature capsule) * Any condition or disease listed as 'Category A' in NFPA 1582 that would disqualify a person as a firefighter. * Current use of NSAIDS or steroid drugs (oral or nasal). * Consumption of caffeine, nicotine, or alcohol in the preceding 12-hours. * Dehydration (urine specific gravity over 1.030) * Recent cold/flu (at least 7-days clear of symptom resolution) * No use of antibiotics in preceding 14-days. * Dosing of medication that is known to exhibit adverse reactions with desloratadine dosing.