RecruitingPhase 4

Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age

Finland210 participantsStarted 2022-10-11

Plain-language summary

The aim of the trial is to evaluate whether the use of oral prednisolone directed by point-of-care testing is useful in acute wheezing caused by rhinovirus in children aged 6-24 months.

Who can participate

Age range

6 Months – 24 Months

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Wheezing bronchitis diagnosed by a physician * Need for salbutamol treatment at the emergency department * Positive nasopharyngeal rhinovirus or picornavirus finding in point-of-care testing Exclusion Criteria: * Need for immediate resuscitation * Immediate transfer to ICU * Suspected pneumonia based on the auscultation finding * Suspected serious bacterial infection * Other respiratory virus finding in the absence of rhinovirus or picornavirus * Positive respiratory syncytial virus finding * Positive SARS-coronavirus-2 finding * Positive Mycoplasma pneumoniae finding * Positive Bordetella pertussis finding * Contact with a person with chickenpox within 14 days * Active chickenpox * Suspected foreign body of the respiratory tract * Immunosuppressive treatment * Systemic corticosteroid treatment within 14 days * Allergy to corticosteroids

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Length of hospital stay

Timeframe: Within 7 days of study entry

Trial details

NCT IDNCT05444699

SponsorUniversity of Oulu

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

Contact for this trial

Ville Lindholm, MD

+35883155283 Ville.a.lindholm@oulu.fi

View on ClinicalTrials.gov More Bronchiolitis Acute Viral trials

Who can participate

Age range

6 Months – 24 Months

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.