CompletedNot Applicable

Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy

Egypt100 participantsStarted 2024-01-20

Plain-language summary

* Detection of primary antimicrobial susceptibility and resistance of Helicobacter Pylori infection. * Detection of resistance and virulence genes of Helicobacter Pylori infection. * Assessment of H pylori carcinogenicity gene. * Evaluation of outcome and efficacy of antibiotics regimen will be used in our research. * Evaluation of effect of other factors as diet (fatty and spicy meal), drugs as NSAIDs use, antibiotics for any cause on response of H pylori to antibiotics regimen.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- Any patient is above 18 years old with symptomatic H pylori infection patients diagnosed by positive H pylori Ag in stool (naïve treatment). Exclusion Criteria: * Patients who aren't eligible to endoscopy. * Patients are under 18 years old * Patient's refusal * history of antibiotics or proton pump inhibitor use during last month.

What they're measuring

detection of pre treatment antibiotic culture and sensitivity test

Timeframe: up to 12 months

detection of vacuolating cytotoxin A and cytotoxin-associated gene A virulent Helicobacter Pylori genotypes by polymerase chain reaction amplification(PCR)

Timeframe: up to 12 months

Relation of histopathological examination (gastritis classification) to clinical presentation and to resistance.

Timeframe: up to 12 months

Trial details

NCT IDNCT05444439

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-09-15

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