Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications

Inclusion Criteria: * Patient aged 18 years or above * Admission in Intense/Intermediate Care Unit * Severe DKA due to all types of diabetes (T1D, T2D and secondary diabetes and inaugural ketoacidosis) defined by association of the following 3 parameters: * glucose \> 11 mmol/L or affirmation of having diabetes * ketonemia \> 3mmol/L or ketonuria ≥ 2 * bicarbonate \< 15 mmol/L and/or venous pH \< or=7.3 * Randomization possible before 15UI of insulin administrated in total * Informed and written consent. In the absence of parent/ relative/ person of trust, the patient may be included via the emergency procedure and consent will be obtained as soon as possible Exclusion Criteria: * Non-diabetic ketoacidosis (fasting or alcoholic) * Patient weighing less than 30 kg * Hypokalemia \< 3.5 mmol/L at the time of inclusion * Hyperosmolar hyperglycemic state (defined as efficient plasma osmolarity \> 320 mosmol/L) * Absence of social security coverage * Pregnant or breastfeeding patient * Patient under tutelage or curators * Patient deprived of liberty due to a judicial or administrative decision * Patient with a renal disease requiring dialysis * Acute or chronic liver failure with Factor V \< 50% * Patient receiving a high dose of corticosteroids (≥ 0.5 mg/kg) daily * Patient included in another interventional study