The purpose of this study is to measure the benefit of adding abemaciclib to chemotherapy (irinotecan and temozolomide) for Ewing's sarcoma that has come back or did not respond to treatment. This trial is part of the CAMPFIRE master protocol, which is a platform to speed development of new treatments for children and young adults with cancer. Your participation in this trial could last 11 months or longer, depending on how you and your tumor respond.
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Progression Free Survival (PFS) Assessed by Blinded Independent Review Committee (BIRC) by Bayesian Analysis
Timeframe: From Date of Randomization until Disease Progression or Death Due to Any Cause (Up to 22.36 months)
PFS Assessed by BIRC by Frequentist Analysis
Timeframe: From Date of Randomization until Disease Progression or Death Due to Any Cause (Up to 22.36 months)