A Study to Evaluate the Safety, Tolerability and Efficacy of AK3280 Cream on Hypertrophic Scar

Inclusion Criteria: * 1\) Patients who sign informed consent before participating in the study. * 2\) Patients aged between 18 and 60 (including 18 and 60). * 3)Patients who understand and be willing to follow the study procedure and be able to complete the whole process of the study. * 4\) Patients with visible hypertrophic scars in any location other than the face and anterior middle and upper neck caused by trauma or surgery and planned for surgical treatment. * 5\) Patients with postoperative scar length ≥ 6 cm, and preoperative scar length ≥4cm. * 6\) Women of childbearing age should have negative serum pregnancy test during screening period and on study day 1. Exclusion Criteria: * 1\) Patients who were systematically treated or topically treated with corticosteroids or immunosuppressants during the 30 days prior to the screening period; * 2\) Patients who accepted systematically chemotherapy during 30 days prior to the screening period; * 3\) Patients whose hypertrophic scars are being locally infected, or with sepsis; * 4\) Hypertrophic scar patients with potential keloid trend or keloid history; * 5\) Patients with autoimmune diseases or immune insufficiency or defects * 6)Patient with uncontrolled diabetes - HbA1c (glycosylated hemoglobin A1c) ≥ 8% ，with peripheral neuropathy, peripheral arterial atresia, or other vascular diseases; * 7\) Patients with abnormal anticoagulation or coagulation function; * 8\) Patients with atrophic skin diseases, rheumatism or hemo…