High Dose Inspiratory Muscle Training in LOPD

Inclusion Criteria: * Age ≥ 18 years * Confirmed diagnosis of LOPD * MIP \>50% of predicted for sex and age * Stable on current Pompe disease treatment regimen \>6 months * Able to follow directions for study participation * Access to computer and smartphone/tablet with reliable internet connection for video visits and sensor-based respiratory technologies Exclusion Criteria: * Presence of medical comorbidities that prevent meaningful study participation (e.g., COPD GOLD III-IV, significant mental illness, dementia) * Use of continuous invasive or non-invasive ventilation while awake * Prior history of gene therapy for LOPD * Inability to give legally effective consent * Inability to read and understand English