Preclinical Evaluation of Multimodal Therapeutic Strategies in Intestinal Irradiation and Inflammatory Bowel Disease From Organoids

Inclusion criteria: \- Group 1: active IBD * 18 years old or older * Assured IBD diagnosis (Crohn's disease/ulcerative colitis) according to European Crohn's and Colitis Organisation (ECCO) 2019 consensus criteria * Active IBD (Harvey-Bradshaw score of 4 or above for Crohn's disease or partial Mayo score of 3 or above for ulcerative colitis) * Indication to perform a coloscopy * Written consent for study participation obtained Or \- Group 2: inactive IBD * 18 years old or older * Assured IBD diagnosis (Crohn's disease/ulcerative colitis) according to ECCO 2019 consensus criteria * Inactive IBD (Harvey-Bradshaw score below 4 for Crohn's disease or partial Mayo score below 3 for ulcerative colitis) * Indication to perform a coloscopy * Written consent for study participation obtained Or \- Group 3: Control * 18 years old or older * Indication to perform a coloscopy to detect polyp * No known bowel disease * Written consent for study participation obtained Exclusion Criteria: * Inability to understand, read, sign informed consent and/or express consent * Person subject to legal protection (curator, guardianship or safeguard of justice), * Deprivation of liberty by judicial or administrative decision, * Non-affiliation to a social security scheme or non-beneficiary of such a scheme * Pregnant, parturient, breastfeeding women * Contraindication to performing biopsies * Participation in other therapeutic research that may modify the behavior of intestinal cells (for examp…