Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities

Inclusion Criteria for randomized participants: * Have at least 20 natural teeth with a diagnosis of Periodontitis (stage II, III, or IV). Inclusion Criteria for periodontally-healthy participants: * Diagnosis of healthy periodontium defined as ≤9% of sites bleeding on probing with absence of interproximal attachment loss and bone loss Exclusion Criteria for all participants: * Pregnancy or lactation * Patients with diabetes mellitus or any other systemic disease that can modify periodontitis * Current smokers * Current use of f any medication with known effects on periodontitis * Use of non-steroidal anti-inflammatory drugs * Use of local or systemic antibiotics within the last 3 months * Subjects with conditions requiring prophylactic antibiotics * Subjects allergic to any of the tetracyclines * Professional dental cleaning within the last 3 months * SRP or surgical periodontal therapy in the previous year