Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbi… (NCT05422742) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities
United States50 participantsStarted 2021-10-15
Plain-language summary
The purpose of this study is to characterize the effect of minocycline microspheres (MM) administered as an adjunct to scaling and rooting planning (SRP) on the subgingival community composition and metatranscriptome functional profile, in comparison to a group treated with SRP only and to periodontally-healthy subjects.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for randomized participants:
* Have at least 20 natural teeth with a diagnosis of Periodontitis (stage II, III, or IV).
Inclusion Criteria for periodontally-healthy participants:
* Diagnosis of healthy periodontium defined as ≤9% of sites bleeding on probing with absence of interproximal attachment loss and bone loss
Exclusion Criteria for all participants:
* Pregnancy or lactation
* Patients with diabetes mellitus or any other systemic disease that can modify periodontitis
* Current smokers
* Current use of f any medication with known effects on periodontitis
* Use of non-steroidal anti-inflammatory drugs
* Use of local or systemic antibiotics within the last 3 months
* Subjects with conditions requiring prophylactic antibiotics
* Subjects allergic to any of the tetracyclines
* Professional dental cleaning within the last 3 months
* SRP or surgical periodontal therapy in the previous year
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.