A Prospective, Multicenter Study to Evaluate the JensClip Transcatheter Valve Repair System

Inclusion Criteria: * Age ≥ 18 years; * Echocardiographically confirmed moderate-severe or severe degenerative mitral regurgitation (regurgitation degree MR ≥ 3+); * NYHA Classification II-IV. * LVEF ≥ 20% * Patients considered at high surgical risk after evaluation by two or more cardiovascular specialists (American Association for Thoracic Surgery STS score: risk of death from mitral valve repair ≥ 6% or from mitral valve replacement ≥ 8% (high risk); or the presence of 2 or more indices of frailty (moderate to severe frailty); or the presence of 2 or more major organ insufficiencies that do not improve postoperatively; or a comprehensive cardiac team assessment that the patient has other combined diseases or factors that make him or her unsuitable for surgery) * Anatomically suitable for mitral valve repair and assessed as suitable for use of this investigational device. * Voluntarily participate and sign an informed consent form and be willing to accept relevant examinations and clinical follow-up. Exclusion Criteria: * Severe mitral valve calcification * Previous implantation of a prosthetic mitral valvuloplasty ring or prosthetic mitral valve, or previous transcatheter mitral valve surgery * Patients with active infective endocarditis * Patients with mitral stenosis * Any intracardiac mass, left ventricular or atrial thrombus detected by echocardiography * Severe coronary stenosis without surgical or interventional treatment or an acute myocardial infarction within 9…