CompletedPhase 4

Effect of S-ketamine in Cesarean Section Combined Anesthesia

China120 participantsStarted 2022-06-14

Plain-language summary

To compare the anti-hyperalgesia effect between S-ketamine with placebo for Maternal receiving elective Cesarean Section under Combined spinal and epidural analgesia. Based on this study the investigators intend to verify the role and potential mechanism of S-ketamine combined anesthesia in alleviating hyperalgesia after cesarean section, prove that it can reduce hyperalgesia and postoperative pain. explore the role of S-ketamine in alleviating postoperative hyperalgesia in different PCA ways and explore the safety of S-ketamine in the perilactation

Who can participate

Age range

20 Years – 45 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ASA status I-III * Age 20 to 45 * 37-42 weeks gestation * undergo elective cesarean section with subarachnoid anesthesia * participate in this study and sign informed consent Exclusion Criteria: * Patients with contraindications for cesarean section * Patients with contraindications of combined spinal and epidural anesthesia * Patients with severe systemic disease * Alcoholism and long-term use of anti-inflammatory and analgesic drugs * Patients who were unable to cooperate or refused to participate in the trial * Patients with contraindications to esketamine and hydromorphone

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Maximum pain score (NRS socre) at 0-24 hours postoperatively

Timeframe: From ending of the surgery to 24 hours postoperatively

Pain score (NRS socre) at 0-6 hours postoperatively

Timeframe: From ending of the surgery to 6 hours postoperatively

Pain score (NRS socre) at 6-12 hours postoperatively

Timeframe: From 6 hours postoperatively to 12 hours postoperatively

Pain score (NRS socre) at 12-24 hours postoperatively

Timeframe: From 12 hours postoperatively to 24 hours postoperatively

Trial details

NCT IDNCT05414006

SponsorThe Second Affiliated Hospital of Chongqing Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-08-31

View on ClinicalTrials.gov More Postoperative Pain trials