UnknownNot Applicable

Computerized Cognitive Remediation Therapy in Adolescents With a First Psychotic Episode

Spain50 participantsStarted 2019-03-19

Plain-language summary

Cognitive deficits (CD) are considered one of the essential characteristics in psychotic disorders and occur throughout the course of the disease, being a key characteristic in the evolution of the disease and in the functionality and prognosis of patients. Intervening in the early stages of the disease and specifically in adolescence, a period of high brain plasticity can reduce disabilities in adulthood associated with early-onset psychosis. The objective of this study is to assess the efficacy of cognitive rehabilitation therapy in adolescents with a first psychotic episode, comparing two groups of these patients: a first group (CCRT) will carry out 40 sessions of a computerized cognitive remediation therapy with the usual treatment too, and a second group will perform only the usual treatment (TAU). The main hypothesis is that the CCRT group will present a significant improvement in verbal memory, visual attention, executive function, and social cognition and will present better global functioning compared to the TAU group.

Who can participate

Age range

12 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. 2 discrepant scores (a score is discrepant when the T scores are 1 DE below the patient's estimated IQ
. Either a score T below 37 in persevering Wisconsin Card Sorting Test (WCST) errors by Heaton et al. (1981).

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Global Functioning

Timeframe: 1 week

Global Functioning

Timeframe: 5 months

Global Functioning

Timeframe: 11 months

Long term Verbal Memory

Timeframe: 1 week

Long term Verbal Memory

Timeframe: 5 months

Long term Verbal Memory

Timeframe: 11 months

Verbal Memory, Learning

Timeframe: 1 week

Verbal Memory, Learning

Timeframe: 5 months

Trial details

NCT IDNCT05405946

SponsorFundació Sant Joan de Déu

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03

Contact for this trial

Ester Camprodon Rosanas, Psychology

. +34 677056074 ester.camprodon@sjd.es

View on ClinicalTrials.gov More Early-onset Schizophrenia trials

Plain-language summary

Who can participate

Age range

12 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. 2 discrepant scores (a score is discrepant when the T scores are 1 DE below the patient's estimated IQ
. Either a score T below 37 in persevering Wisconsin Card Sorting Test (WCST) errors by Heaton et al. (1981).

What they're measuring

Global Functioning

Timeframe: 1 week

Global Functioning

Timeframe: 5 months

Global Functioning

Timeframe: 11 months

Long term Verbal Memory

Timeframe: 1 week

Long term Verbal Memory

Timeframe: 5 months

Long term Verbal Memory

Timeframe: 11 months

Verbal Memory, Learning

Timeframe: 1 week

Verbal Memory, Learning

Timeframe: 5 months