A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum (NCT05398250) | Clinical Trial Compass
By InvitationNot Applicable
A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
United States1,665 participantsStarted 2022-08-23
Plain-language summary
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die by suicide. Autistic individuals have identified suicide prevention as a top research priority; however, little is known about how to best help autistic youth at risk for suicide. The purpose of this study is to compare the effectiveness, feasibility, and acceptability of two suicide prevention strategies tailored for autistic individuals: the Safety Planning Intervention tailored for Autistic individuals (SPI-A) and SPI-A plus structured follow-up contacts (SPI-A+).
Who can participate
Age range
12 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
(A) Patient Participants
Please note that that eligibility criteria differ for each distinct patient subgroup as defined below.
A.1 - Basic EHR-Only Arm
Inclusion criteria:
* 12-24 years old
* Scheduled for a clinical visit with a consented clinician Exclusion criteria: None
A.2 - Enhanced EHR-Only Arm:
Inclusion criteria:
* Meets inclusion criteria for the Basic EHR-Only arm
* Receives one of the interventions being studied (SPI-A or SPI-A+) as part of routine clinical care
Exclusion criteria: Presence of documentation that the patient declines all research participation
A.3 - Active PRO Arm:
Inclusion Criteria:
* Meets inclusion criteria for the Enhanced EHR-Only arm
* Referred to the study team by a consented clinician
* Able and willing to provide informed consent (age 18+) or assent and parental/guardian consent (age \< 18)
* Able to speak English (and, if applicable, at least one guardian also able to speak English)
Exclusion Criteria: Altered mental status that precludes ability to provide informed assent or consent (acute psychosis, intoxication, or mania)
(B) Clinician Participants
Inclusion Criteria:
* Employment as a provider serving autistic patients at one of the study sites
* Employment in a role that involves suicide risk intervention with youth patients at a participating clinic
* Able to read and speak English
* Able and willing to provide informed consent
Exclusion Criteria: None
(C) Health System Leader Participants
Inclusion Criteria:
* …
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.