CompletedNot Applicable

The Impact of Exercise on Hippocampus-dependent Cognition and the Gut Microbiota

United Kingdom52 participantsStarted 2022-03-01

Plain-language summary

The NeuroFit study will be investigating the impact of exercise on global cognition, hippocampus-dependent memory function and the gut microbiota in a middle-aged population.

Who can participate

Age range

45 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. 45 - 65 years of age.
. BMI 20 - 30.
. Does less than 90 minutes of moderate to vigorous physical activity per week and does not have a regular exercise routine(captured by self-reported measures)

Exclusion criteria

. Subject is unable to understand the participant information sheet.
. Subject is unable to provide written informed consent.
. Subject is unable to understand and/or completely perform the cognitive testing.
. Impaired vision that is not corrected.
. Subject is a smoker.
. Does not agree to maintain their habitual dietary routine.
. Unwilling to provide blood and stool samples.
. Is not in general good health on the basis of medical history.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Mnemonic Similarity Task

Timeframe: Change from baseline pattern separation and recognition memory at 12 weeks

Mnemonic Similarity Task

Timeframe: Change from baseline pattern separation and recognition memory at 24 weeks

Trial details

NCT IDNCT05397990

SponsorKing's College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-11-18

View on ClinicalTrials.gov More Cognitive Decline trials