CompletedNot Applicable

The Impact of Exercise on Hippocampus-dependent Cognition and the Gut Microbiota

United Kingdom52 participantsStarted 2022-03-01

Plain-language summary

The NeuroFit study will be investigating the impact of exercise on global cognition, hippocampus-dependent memory function and the gut microbiota in a middle-aged population.

Who can participate

Age range45 Years – 65 Years

SexALL

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Inclusion criteria

✓. 45 - 65 years of age.
✓. BMI 20 - 30.
✓. Does less than 90 minutes of moderate to vigorous physical activity per week and does not have a regular exercise routine(captured by self-reported measures)

Exclusion criteria

✕. Subject is unable to understand the participant information sheet.
✕. Subject is unable to provide written informed consent.
✕. Subject is unable to understand and/or completely perform the cognitive testing.
✕. Impaired vision that is not corrected.
✕. Subject is a smoker.
✕. Does not agree to maintain their habitual dietary routine.
✕. Unwilling to provide blood and stool samples.
✕. Is not in general good health on the basis of medical history.

What they're measuring

Mnemonic Similarity Task

Timeframe: Change from baseline pattern separation and recognition memory at 12 weeks

Mnemonic Similarity Task

Timeframe: Change from baseline pattern separation and recognition memory at 24 weeks

Trial details

NCT IDNCT05397990

SponsorKing's College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-11-18

View on ClinicalTrials.gov More Cognitive Decline trials