RecruitingNot Applicable

Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome

China180 participantsStarted 2022-05-23

Plain-language summary

sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients (LDL-C\>1.8mmol/L) without endovascular therapy.

Who can participate

Age range18 Years – 85 Years

SexALL

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Inclusion criteria

✓. Age ≥18 years
✓. Symptomatic intracranial atherosclerotic stenosis of moderate to severe, did not receive intravenous thrombolysis, thrombectomy, stent implantation and other intravascular treatment
✓. low density lipoprotein cholesterol \> 70mg/dl (1.8mmol/L)
✓. Receive 3T magnetic resonance angiography or multi-mode MR (high resolution is required), angiography can be included, and images for analysis can be obtained.
✓. Lipid-lowering indications of statins
✓. Signed an approved informed consents

Exclusion criteria

✕. Contraindications to statins
✕. There are contraindications to MRI examination or cannot accept MRI examination
✕. Stenosis caused by vasculitis, arterial dissection and moyamoya disease
✕. Patients with active bleeding or obvious bleeding tendency
✕. Severe heart, lung, renal insufficiency, malignant tumor or other malignant diseases, and death is highly likely within 7 days; pregnancy or women who are lactating
✕. Uncontrolled severe diabetes and hypertension
✕. Other conditions inappropriate for inclusion judged by investigators

What they're measuring

Recurrent stroke

Timeframe: 6 months-12 months

Trial details

NCT IDNCT05397405

SponsorNanjing First Hospital, Nanjing Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-01

Contact for this trial

Junshan Zhou

8602587726218 zhjsh333@126.com

View on ClinicalTrials.gov More Intracranial Artery Stenosis trials