Active — Not RecruitingNot Applicable

Characterization of Endocannabinoid and Endogenous Opioid Levels in Adolescents With Cannabis Use Disorder

United States30 participantsStarted 2022-10-13

Plain-language summary

This project seeks to learn more about the effects of cannabis use on the endocannabinoid system and endogenous opioid systems in adolescents to address a fundamental gap in knowledge and identify biomarkers that may help distinguish youth who relapse from youth who remain sober.

Who can participate

Age range14 Years – 25 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. 14 to 25 years of age.
✓. Use cannabis at least twice a week for the past month.

Exclusion criteria

✕. Refusal of valid written consent,
✕. Current psychosis,
✕. Obvious intoxication,
✕. Current risk of suicide,
✕. Violence sufficiently great to interfere with evaluation or to endanger evaluators,
✕. Obvious intellectual deficiency as noted during the informed consent process, or inability of patient or family to comply with the study protocol.
✕. Use of other illicit drugs in the past 90 days by self-report or detected by urine drug test.
✕. Use of opioid medications for medical or recreational purposes currently or within the past 90 days.

What they're measuring

Cannabinoid levels in blood

Timeframe: Collected at Baseline

Cannabinoid levels in blood

Timeframe: Collected at Week 2

Cannabinoid levels in blood

Timeframe: Collected at Week 4

Cannabinoid levels in blood

Timeframe: Collected at Week 8

Endocannabinoid levels in blood

Timeframe: Collected at Baseline

Endocannabinoid levels in blood

Timeframe: Collected at Week 2

Endocannabinoid levels in blood

Timeframe: Collected at Week 4

Endocannabinoid levels in blood

Timeframe: Collected at Week 8

Trial details

NCT IDNCT05396638

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

View on ClinicalTrials.gov More Cannabis Use trials

Who can participate

Age range14 Years – 25 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. 14 to 25 years of age.
✓. Use cannabis at least twice a week for the past month.

Exclusion criteria

✕. Refusal of valid written consent,
✕. Current psychosis,
✕. Obvious intoxication,
✕. Current risk of suicide,
✕. Violence sufficiently great to interfere with evaluation or to endanger evaluators,
✕. Obvious intellectual deficiency as noted during the informed consent process, or inability of patient or family to comply with the study protocol.
✕. Use of other illicit drugs in the past 90 days by self-report or detected by urine drug test.
✕. Use of opioid medications for medical or recreational purposes currently or within the past 90 days.

What they're measuring

Cannabinoid levels in blood

Timeframe: Collected at Baseline

Cannabinoid levels in blood

Timeframe: Collected at Week 2

Cannabinoid levels in blood

Timeframe: Collected at Week 4

Cannabinoid levels in blood

Timeframe: Collected at Week 8

Endocannabinoid levels in blood

Timeframe: Collected at Baseline

Endocannabinoid levels in blood

Timeframe: Collected at Week 2

Endocannabinoid levels in blood

Timeframe: Collected at Week 4

Endocannabinoid levels in blood

Timeframe: Collected at Week 8