Active — Not RecruitingNot Applicable

Blood Vessel Anatomy and Blood Flow Regulation

United States80 participantsStarted 2022-07-19

Plain-language summary

Brain blood flow regulation will be measured in response to environmental changes using MRI.

Who can participate

Age range

55 Years – 69 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * BMI ≤38.5 kg/m2 * Nonsmoker * Female subjects: postmenopausal * Currently enrolled in the Wisconsin Alzheimer's Disease Research Clinical Core Exclusion Criteria: * Diagnosis of mild cognitive impairment or Alzheimer's disease * Uncontrolled hypertension * History or evidence of hepatic disease, hematological disease, or peripheral vascular disease * Severe kidney injury requiring hemodialysis * Cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia * History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease * History of HIV/AIDS * Severe untreated obstructive sleep apnea * History of diabetes with HbA1c greater than 9.5% * Major neurologic disorders other than dementia (e.g., multiple sclerosis, amyotrophic lateral sclerosis, brain surgery, etc.) * Current or recent (\<1 year) major psychiatric condition (Axis I) or addictive disorders * Contraindications to MRI

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This study is looking at how blood vessels in the brain respond to changes in carbon dioxide and oxygen levels — could you help me understand whether that kind of testing would be safe for me given my current health, since it involves intentionally altering the air I breathe?
2Since this trial is listed as 'active not recruiting,' does that mean enrollment is already closed, and if so, are there similar studies on brain blood flow regulation that I could still join?
3This is a Phase NA study, which I understand often means it's more observational or physiological in nature — what would actually happen during the testing sessions, and how much time would I need to commit?
4Because this trial involves healthy participants studying normal brain blood vessel function, would my doctor consider me an appropriate candidate, or would any medical history I have disqualify me from this type of research?
5Are there any risks I should know about from the procedures used to measure how my brain's blood vessels react to low oxygen or high carbon dioxide, even if they seem minor?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Cerebral Vascular Reactivity to Hypercapnia

Timeframe: One study visit, up to 120 minutes in the MRI

Cerebral Blood Flow Response to Hypoxia

Timeframe: One study visit, up to 120 minutes in the MRI

Trial details

NCT IDNCT05396287

SponsorUniversity of Wisconsin, Madison

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-05

View on ClinicalTrials.gov More Brain Blood Flow trials

Who can participate

Age range

55 Years – 69 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.