CompletedNot Applicable

Effect of taVNS on Abdominal Pain and Other Symptoms in Constipation-predominant Irritable Bowel Syndrome

China42 participantsStarted 2020-03-01

Plain-language summary

This study aims to investigate the effects and possible mechanisms of transcutaneous auricular vagal nerve stimulation (taVNS) on abdominal pain and other symptoms in patients with IBS-C.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. willing to sign a written informed consent form
✓. met the Rome IV diagnostic criteria for IBS-C

Exclusion criteria

✕. history of previous abdominal surgery (other than appendectomy)
✕. presence of carcinoma
✕. any organic diseases causing constipation or neurologic diseases such as multiple sclerosis, rachischisis, Parkinson's disease, or spinal cord injury
✕. taking antidepressant agents including tricyclic antidepressants and selective serotonin reuptake inhibitors
✕. serious concomitant disease of the heart, liver, kidney, or diabetes
✕. pregnancy or lactation
✕. participating in another trial or enrolled in a trial during the past month
✕. allergic reaction to surface electrodes

What they're measuring

Change in аbdominal pain between sham and active taVNS

Timeframe: 4 weeks

Trial details

NCT IDNCT05392439

SponsorTongji University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12-15

View on ClinicalTrials.gov More Constipation-predominant Irritable Bowel Syndrome trials