Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study

Inclusion criteria * Diminished ovarian reserves AND/OR; * Anti-Mullerian Hormone (AMH) 0.2-0.5ng/ml or * At least 2 Follicle Stimulating Hormone (FSH) readings of \>25 (mIU/L) or * AFC \< 5 * Poor Ovarian Response of \<4 oocytes retrieved at a prior IVF stimulation cycle with gonadotrophin doses of 450u per day Exclusion criteria * Amenorrhea of \> 1 years * Medical conditions - Diabetes Mellitus, Hypertension, Collagen vascular diseases, Thyroid disease * Patients presenting with anemia and thrombophilic disorders * Inability to be monitored for at least 1 year at the treating centre * Lack of suitable sperm for Intracytoplasmic Sperm Injection (ICSI) (eg. Azoospermia)