Prophylaxis of Post-ERCP Acute Pancreatitis

Inclusion Criteria: * Age \> 18 years; * All naïve patients consecutively undergoing ERCP and with any indication; * Obtaining informed consent. Exclusion Criteria: * Refusal or inability to sign informed consent; * Patients undergoing ERCP for diagnostic purposes only; * Patients with ongoing acute pancreatitis; * Patients with known allergy/hypersensitivity to NSAIDs; * Patients with hypersensitivity to the active ingredients or any of the excipients of Ringer * Lactate; * Patients with a personal or family history of Stevens-Johnson or Lyell syndrome; * Patients already receiving treatment with NSAIDs within 7 days prior to ERCP; * Patients with recent gastrointestinal bleeding (less than 30 days after ERCP), or with history of recurrent bleeding/ulcer peptic ulcer or bleeding/perforation after previous NSAID treatment; * Patients who are candidates for or have previously undergone endoscopic papillectomy; * Patients with a positive history of recent myocardial infarction (less than 6 months after the procedure), heart failure, severe myocardial insufficiency (NYHA class \> II), respiratory failure with chronic need for oxygen therapy, known pulmonary hypertension; * Patients with ventricular fibrillation; * Patients with ongoing therapy with cardioactive glycosides; * Patients with chronic renal failure (creatinine clearance values less than 40 ml/min); * Cirrhotic patients in Child B and C class; * Patients with severe hydro-electrolyte imbalances (hypernatremia \> 15…