CompletedNot Applicable

Chemotherapy Induced Peripheral Neuropathy (CIPN) and Lymphoma Longitudinal Follow-up and Prognostic Factors

France40 participantsStarted 2022-01-10

Plain-language summary

Vincristine-induced peripheral neuropathy, which is commonly a sensorimotor neuropathy, remains a major complication of lymphoma patients treated with R-CHOP. The investigators propose a clinical, electrophysiological and biological follow up of patients treated by vincristine for lymphoma to determine the factors implied in VIPN occurrence.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of indolent or aggressive B/T NHL confirmed by biopsy and requiring chemotherapy after PCR decision including vincristine, RCHOP/CHOP protocol or CHOEP * Accept to participate in the study * Age \> 18 year * Able and willing to provide informed consent * Affiliated to a social security system Exclusion Criteria: * Life-threatening emergency requiring chemotherapy in extreme urgency * Neuro-meningeal damage at diagnosis * Protected person (under guardianship or curators) * Person under court protection * Pregnant or breastfeeding woman * Persons deprived of liberty by judicial or administrative decision * Persons under forced psychiatric care * Persons admitted to a health or social institution for purposes other than research * Persons unable to express their consent

What they're measuring

Nerve conduction parameters

Timeframe: Before Chemotherapy first cure

Nerve conduction parameters

Timeframe: Immediately after 4th Chemotherapy course

Nerve conduction parameters

Timeframe: Immediately at the end of all the Chemotherapy courses

Nerve conduction parameters

Timeframe: 6 months after the end of all the cures

Trial details

NCT IDNCT05378256

SponsorCentre Hospitalier Régional d'Orléans

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-11

View on ClinicalTrials.gov More Lymphoma trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Nerve conduction parameters

Timeframe: Before Chemotherapy first cure

Nerve conduction parameters

Timeframe: Immediately after 4th Chemotherapy course

Nerve conduction parameters

Timeframe: Immediately at the end of all the Chemotherapy courses

Nerve conduction parameters

Timeframe: 6 months after the end of all the cures