Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI (NCT05377242) | Clinical Trial Compass
CompletedNot Applicable
Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI
United States390 participantsStarted 2023-05-31
Plain-language summary
This project's objective is to identify effective treatments for Gulf War Illness (GWI). The project tests three potential treatments: curcumin, stinging nettle, and resveratrol. The project uses a decentralized clinical trial (DCT) design in which individuals can participate from anywhere in the United States. Recruitment efforts will be designed to obtain a geographically and demographically diverse study sample.
Who can participate
Age range
45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
In accordance with the Institute of Medicine (IOM) 2014 guidance, participants must meet both the Kansas and CDC (Centers for Disease Control and Prevention) Case Definitions of GWI. Participants must have been deployed to the Persian Gulf Region during the 1990-1991 Gulf War, meet symptom domain criteria, and not have exclusionary medical conditions. The case definitions will be used for inclusionary screening purposes.
Inclusion Criteria:
* Meets Kansas GWI Case Definition
* Meets CDC GWI Case Definition
* Able to commit to a 10-month study
Exclusion Criteria:
* Currently involved in an experimental treatment study
* Abnormal liver function values
* Abnormal kidney function values
* Currently pregnant
* Blood clotting disorder (contraindicated with all three botanicals)
* Reported diagnosis of diabetes with an A1C greater than 9
* The use of contraindicated medications (see below):
* Anticoagulant medications (such as warfarin, heparin, etc.)
* Lithium
* Tacrolimus (Prograf)
* Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is using three natural supplements — curcumin, resveratrol, and stinging nettle — to treat Gulf War Illness; do you think there's enough existing evidence on any of these to suggest they could genuinely help my specific symptoms, or is this still very early-stage exploration?
2Since this trial is listed as 'active, not recruiting,' it sounds like enrollment is already closed — is there any way to find out if results are expected soon, and would it be worth waiting for those findings before making decisions about my treatment plan?
3The trial is measuring outcomes using the VR-12 survey, which covers both physical and mental functioning — given my particular Gulf War Illness symptoms, do you think physical functioning, mental functioning, or both are the most important areas to target right now?
4This trial doesn't have a traditional phase listed, which makes me unsure how much is known about the safety of combining curcumin, resveratrol, and stinging nettle together — are there any known interactions or risks with these supplements I should be aware of, especially given any medications I'm already taking?
5Are there any standard treatments or other active clinical trials for Gulf War Illness that you'd recommend I consider alongside or instead of waiting for the results from this supplement-based study?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Average Veterans Rand 12-Item Health Survey (VR-12) Physical Functioning Score
Timeframe: This outcome will be assessed weekly, for up to 44 weeks.
2
Average Veterans Rand 12-Item Health Survey (VR-12) Mental Functioning Score
Timeframe: This outcome will be assessed weekly, for up to 44 weeks.