Low-dose Quadruple Combination Therapy in Patients With Hypertension

Inclusion Criteria: * Age ≥18 years, \< 80 years old； * Have never taken antihypertensive medications or have not taken antihypertensive medications in the past 1 month； * Patients with hypertension (meet the following two parameters to avoid white coat hypertension):a. Office Blood Pressure: systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg measured 3 times on different days;b. ABPM: average blood pressure of 24h ≥130/80 mmHg; Or average blood pressure of daytime ≥135/85 mmHg; Or average blood pressure of night ≥120/70 mmHg; * Participate voluntarily and sign written informed consent. Exclusion Criteria: * Confirmed or highly suspected secondary hypertension, such as primary aldosteronism, Cushing's syndrome, pheochromocytoma or paraganglioma, aortic constriction, renal arterial stenosis, renal hypertension, hyperthyroidism, etc.; * Severe hypertension: systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg in the consulting room or hypertensive emergency or urgency at the time of visit; * Differences in blood pressure of both upper limbs ≥20/10mmHg; * Allergic to irbesartan, metoprolol, amlodipine, indapamide and sulfonamides; * Cannot swallow tablets; * Pregnant and lactating women; * Possible reproductive needs during the trial; * Uncorrected electrolyte disorder (serum potassium \> 5.5mmol/L or \< 3.5mmol/L, serum sodium \< 135mmol/L); * Severe organ dysfunction, including impaired renal function (GFR \< 60mL /min/1.73m\^2…