The main purposes of this study are: I. To assess that the four habitats within the tumor (HAT and LAT) and edema (IPE and VPE) in high-grade glioma are different at vascular, tissular, cellular and molecular levels. II. To analyze the associations between the perfusion imaging markers and relevant molecular markers at the HTS habitats for high-grade glioma diagnosis, prognosis/aggressiveness, progression and/or prediction. III. To analyze the associations between the perfusion imaging markers and immune markers at the HTS habitats useful in immunotherapy evaluation and/or patient selection. IV. To prospectively validate the prognostic capacity (association with OS and PFS) and stratification capacity of the perfusion imaging markers calculated at the HTS habitats.
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Molecular profile of each vascular habitat biopsied for each included patient
Timeframe: through study completion, an average of 1 year
Description at cellular level of each vascular habitat biopsied for each included patient, including cell types and cell density
Timeframe: through study completion, an average of 1 year
Description at histopathological level of each vascular habitat biopsied for each included patient, including tissues, necrosis, vascularuture
Timeframe: through study completion, an average of 1 year