Long-term COVID and Rehabilitation (NCT05373043) | Clinical Trial Compass
RecruitingNot Applicable
Long-term COVID and Rehabilitation
United States300 participantsStarted 2022-11-01
Plain-language summary
The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis
* Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis
* Ability to sign informed consent
Exclusion Criteria:
* BMI \>45 kg/m2
* Unstable (\<6 months) or severe coronary artery disease (CAD-RADS score = 4A), peripheral artery disease (Ankle Brachial Index \<0.40), cerebrovascular disease (identified by previous stroke in last 12 months), severe COPD (=Stage III), uncontrolled hypertension (\>160/100 mmHg), chronic kidney disease requiring dialysis, severe renal insufficiency (creatinine clearance \<30 by the Cockcroft-Gault formula), Alzheimer's disease, dementia
* Orthopedic limitations that would prohibit exercise
* Current smokers and individuals that stopped smoking in the last 10 years
* Already taking Mito-Q or unwilling to cease dietary supplements for participation
* Any other condition or event considered exclusionary by the PIs or a physician
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is measuring blood vessel and circulation changes — things like how well my blood vessels dilate and how blood flows to my brain — so would these types of vascular problems actually match what's happening with my Long COVID symptoms, and is that worth investigating in my case?
2The trial is listed as 'Phase NA,' which often means it's more of an observational or early-stage study — what does that mean for how much is already known about whether the rehabilitation approach being studied is safe and effective for people with Long COVID?
3Since the trial is actively recruiting right now, how quickly would I need to make a decision, and what would participation actually involve day-to-day — like how many visits, what kinds of tests, and how disruptive might that be to my current routine and recovery?
4Before considering a trial like this, would it make more sense for me to first try any standard rehabilitation or treatment options that already exist for Long COVID, and how does this study compare to those in terms of what I might gain?
5The trial is measuring cerebral vascular function using a breath-hold test — are there any risks involved in that kind of assessment for someone with my current health status, and is there anything about my specific Long COVID symptoms that might make any of these tests harder or riskier for me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Flow Mediated Dilation (FMD)
Timeframe: Baseline, months 3 and 6, and every 6 months thereafter until the end of year 4.
2
Change in Microvascular Function with passive leg movement (PLM)
Timeframe: Baseline, months 3 and 6, and every 6 months thereafter until the end of year 4.
3
Change in Cerebral Vascular Endothelial Function with Breath Hold Acceleration Index (BHAI)
Timeframe: Baseline, months 3 and 6, and every 6 months thereafter until the end of year 4.