Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation (NCT05368350) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
United States12 participantsStarted 2022-06-01
Plain-language summary
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area and left inferior frontal gyrus) thought to aid in memory will improve speech and language difficulties in patients with primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS). The primary outcome measures are neuropsychological assessments of speech and language functions, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 18 to 85 years of age
* A formal diagnosis of primary progressive aphasia (nonfluent/agrammatic, semantic, logopenic variants or mixed) and/or progressive apraxia of speech
* Capable of understanding and signing an informed consent. Medical information/history, as well as mental status exam and diagnosis provided by referring physician will determine whether or not a caregiver is required to be involved during this process.
Exclusion Criteria:
* Has an implanted device, such as a pacemaker, metallic cranial implant, or a neurostimulator
* Skull defects
* Pregnant
* A significant history of arrhythmia or epileptic seizures.
* Not a native English speaker
* Currently receiving speech-language intervention
* Unable to communicated verbally
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The Controlled Oral Word Association Test
Timeframe: Treatment change from Baseline to Immediate post, and 8 weeks post treatment completion.
2
Category Fluency
Timeframe: Treatment change from Baseline to Immediate post, and 8 weeks post treatment completion.
3
The Boston Naming Test
Timeframe: Treatment change from Baseline to Immediate post, and 8 weeks post treatment completion.
4
Spontaneous speech (content and fluency) of the Western Aphasia Battery-Revised
Timeframe: Treatment change from Baseline to Immediate post, and 8 weeks post treatment completion.
5
The Apraxia battery for Adults - 2 (ABA - 2)
Timeframe: Treatment change from Baseline to Immediate post, and 8 weeks post treatment completion.