CompletedNot Applicable

Freeze All Strategy Versus Fresh Embryo Transfer After GnRH Analogue Trigger

1,396 participantsStarted 2012-01-01

Plain-language summary

Ovarian hyperstimulation syndrome (OHSS) is one of the most dangerous complications of assisted reproduction technology (ART), described in approximatively 3 to 10% of stimulation cycles although an underestimation of the real incidence has been suggested. The use in clinical practice of GnRH antagonist has made it possible to perform the trigger with GnRH analogues, with the advantage of considerably reducing the risk of OHSS.

Who can participate

Age range20 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients undergoing ART cycle with antagonist protocol stimulation and trigger with GnRH agonist * patients are believed at risk of OHSS at time of trigger based on size and number of follicles developed (≥18 follicles with diameter 12 mm at induction). Exclusion Criteria: * hypogonadotropic hypogonadism * other ART protocols * any patient that underwent freeze-all strategy in order to perform pre-implantation genetic testing (PGT) * oncological or deferring motherhood freezing procedures

What they're measuring

ongoing pregnancy rate

Timeframe: 8 years

delivery rate

Timeframe: 8 years

Trial details

NCT IDNCT05362734

SponsorIstituto Clinico Humanitas

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-12-31

View on ClinicalTrials.gov More Ovarian Hyperstimulation Syndrome trials