Topical Nicotinamide in Treatment of DLE

Inclusion Criteria: * Age: between 18 years and 65 years old * Patients clinically and histopathologically newly diagnosed as DLE * Patients clinically and histopathologically diagnosed with cutaneous lupus erythematosus that has not responded to treatment with hydroxychloroquine(200-400mg/day) plus corticosteroid at a dosage less than the equivalent of (0.5mg/kg/day) for the preceding two months or a longer period Exclusion Criteria: * Age \< 18 years old * Pregnant and lactating women * A history of treatments with multivitamins in the recent month * Soft tissue infection * Severe comorbidities including heart failure, respiratory failure * Acute severe infections such as cellulitis or a history of HBV or HCV