CompletedPhase 4

Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock

Turkey (Türkiye)85 participantsStarted 2019-12-02

Plain-language summary

Septic shock is a clinical condition that is defined as a subset of sepsis that causes very high mortality and morbidity. Surviving sepsis campaign guideline states that the target mean arterial pressure should be 65 mmHg and above in septic shock patients. It is known that abdominal pressure increases and perfusion of intra-abdominal organs decreases in septic shock patients. With this study, we aim to investigate the effects of targeted abdominal perfusion pressure (60 mmHg and above) on renal injury, reversal of renal injury, liver functions and ultimately mortality in patients with septic shock.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Diagnosis of septicemia according to "Surviving Sepsis Campaign Guidelines 2021" * Age lower than 18 Exclusion Criteria: * Reason of admission: Cardiac arrest * Pregnancy * Abdominal surgery in the past 90 days * Pre-diagnosis of end-stage renal disease * History of abdominal trauma * Body mass index of 30 and above * Trauma, bleeding or cerebrovascular event that causes increased intracranial pressure

What they're measuring

Change of the Level of Acute Kidney Injury

Timeframe: up to 90 days

Mortality

Timeframe: at 30th day of admission

Mortality

Timeframe: at 90th day of admission

Trial details

NCT IDNCT05358912

SponsorBozyaka Training and Research Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-09-10

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