UnknownNot Applicable

Effect of Probiotics on Oral Candida Among Denture Wearers

Egypt50 participantsStarted 2022-05-01

Plain-language summary

Forty-eight denture wearers with detectable levels of candida colonization without clinical symptoms will be randomly allocated into two groups: probiotics and placebo. All patients will take a daily dose of chewable tablets (probiotics or placebo according to the assigned group) for 8 weeks. Samples of mouth rinse will be collected from patients at baseline, 4 weeks from the beginning of the intervention, 8 weeks (the end of intervention), and after another 4 weeks for post-intervention follow up. Samples will be tested for both candida count and candida species identification

Who can participate

Age range40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Detectable levels of Candida in palatal mucosa without clinical symptoms of active candidiasis. * Completely edentulous arches with newly formed denture . * Patients with controlled hypertension, and diabetes will be included in this study as they are considered very common problems in the targeted population. Exclusion Criteria: * Inability to understand/ follow the experimental procedures, * Administration of topic or systemic antifungal or antibacterial agents in the previous 60 days. * Consumption of probiotics. * GITdisorders. * Heartdisease. * Diseases that significantly influence immunity such as; kidney problems, head and neck cancer, or radiotherapy, AIDS, or immunosuppressive therapy. * Clinical manifestations of oral candidiasis.

What they're measuring

Change in candida count

Timeframe: Baseline, 4 weeks, 8 weeks, 12 weeks

Trial details

NCT IDNCT05358743

SponsorHams Hamed Abdelrahman

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-01-30

View on ClinicalTrials.gov More Oral Candida Albicans Infection trials