The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo).
Age range
18 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Time weighted average mean arterial pressure within treatment arm
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
Average within treatment arm vasopressor use by number of units
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
Average within treatment arm total minutes under 92% oxygen saturation
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
% of cases with any MAP below 50
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
% of cases with any MAP >60% below patient's immediate preoperative MAP
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
% of cases with any treatment for Post Operative Nausea and Vomiting
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
% of cases with any oxygen saturation event below 85% by pulse oximetry
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
% of cases with any rapid response or code blue event within 24 hours from anesthesia start
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
Within treatment arm % of total group with a composite MACE event in the 30 days
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
Within treatment arm % of total group with a classic MACE event in the 30 days
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
Average within treatment arm antiemetic use by number of doses
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete
Average within treatment arm time in minutes after dressing complete to discharge
Timeframe: Throughout entire study estimated to take 6 to 12 months to complete