The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints.
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Photoreceptor (PR) density
Timeframe: PR density will be calculated once at the AO imaging session in which PRs are the target.
Retinal pigment epithelial (RPE) cell density
Timeframe: RPE cell density will be calculated once at the AO imaging session in which RPE cells are the target.
RPE cell organelle motility
Timeframe: RPE motility will be calculated once at the AO imaging session in which RPE cells are the target. For the reproducibility portion of the study, RPE organelle motility will be quantified three times separated by 1-2 weeks.
PR cell function
Timeframe: PR function will be calculated once at the AO imaging session in which PR cells are stimulated. For the reproducibility portion of the study, PR cell function will be quantified three times separated by 1-2 weeks.