Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients (NCT05354648) | Clinical Trial Compass
CompletedNot Applicable
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
120 participantsStarted 2015-06-01
Plain-language summary
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases. The heart is subjected to a long period of ischemia due to the occlusion of the aorta. The heavy burden of myocardial ischemia-reperfusion injury (IRI) thus induces cardiomyocyte death, which can paradoxically reduce the beneficial effect of CABG. Preconditioning by moderate hypoxia or hyperoxia serves as an effective drug-free method to increase the organism's resistance to negative effects, including IRI.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* the need for coronary artery bypass grafting (CABG)
Exclusion Criteria:
* age over 75 years
* emergency surgery
* diabetes mellitus
* exacerbation of a chronic disease 1 week before surgery
* any oncological disease at the time of the examination
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial tested a 'hypoxic-hyperoxic preconditioning' approach in heart surgery patients — can you explain what that actually involves, alternating low and high oxygen levels before surgery, and whether anything learned from this completed study might be relevant to my own coronary artery disease treatment?
2Since this trial tracked things like mechanical ventilation time and whether patients got their normal heart rhythm back on their own after surgery, what do those outcomes tell us about the real-world risks I might face during or after my own cardiac procedure?
3This study is listed as 'Phase NA,' which often means it's more of an exploratory or procedural study rather than a late-stage drug trial — does that mean the findings are still considered preliminary, and how much weight should I give them when thinking about my options?
4The trial focused on myocardial reperfusion injury, which is damage that can happen when blood flow returns to the heart after being cut off — how significant is that risk for the specific surgery or procedure I'm being considered for?
5Are there standard, already-approved strategies to reduce reperfusion injury or protect my heart during surgery that I should consider first, before looking at approaches that were only recently studied in a trial like this one?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.