The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals with prediabetes. FMD of the brachial artery, pulse wave velocity (PWV), central blood pressure (cBP), and Optical Coherence Tomography Angiography (OCTA) of the eye will be used for vascular assessments. The research plan will also explore cognitive and kidney function benefits of regular avocado and mango intake using specified cognitive tasks and kidney function biomarkers
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Changes in vascular function measured by Flow-mediated vasodilation of brachial artery
Timeframe: baseline-8 weeks
Changes in Pulse Wave Velocity
Timeframe: baseline-8 weeks
Changes in Central Blood pressure
Timeframe: baseline-8 weeks
Changes in plasma biomarkers:fasting glucose
Timeframe: baseline-8 weeks
Changes in plasma biomarkers: fasting insulin
Timeframe: baseline-8 weeks
Changes in plasma biomarkers:lipid profile
Timeframe: baseline-8 weeks
Changes in plasma biomarkers and measures of inflammation concentration: IL-6
Timeframe: baseline-8 weeks
Changes in plasma biomarkers and measures of inflammation concentration: ICAM
Timeframe: baseline-8 weeks
Changes in plasma biomarkers and measures of inflammation concentration: VCAM
Timeframe: baseline-8 weeks
Changes in plasma biomarkers and measures of brain-derived neurotrophic factor: BDNF
Timeframe: baseline-8 weeks
Changes in plasma biomarkers and measures of brain-derived neurotrophic factor: IGF1
Timeframe: baseline-8 weeks
Changes in Kidney function markers
Timeframe: baseline-8 weeks