CompletedNot Applicable

PET MYOCARDIAL Blood Flow Comparison to Coronary CTA and CT-FFR

United States21 participantsStarted 2019-06-06

Plain-language summary

The broad, long-term objective of this pilot study is to develop an optimal, clinically usable, non-invasive evaluation of Coronary Artery Disease (CAD) in the setting of stable angina which provides both anatomic and functional information. Patients already scheduled to undergo Invasive coronary catheterization (ICA) for the clinical indication of angina will be recruited to under go stress-rest Positron Emission Tomography-Coronary CT Angiography-Fractional Flow Reserve (PET-cCTA-cFFR)

Who can participate

Age range18 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18-90 years of age, of either sex * Patients presenting with stable angina and a moderate pretest likelihood for CAD and scheduled to undergo ICA for the clinical indication of angina. Subjects will undergo this study within 45 days prior to the cardiac catheterization. This study can also be performed 45 days after the cardiac catheterization if the patient had no interventions. Exclusion Criteria: * Prior history of stenting, coronary artery bypass graft surgery, or myocardial infarction, unstable angina, atrial fibrillation, second or third degree atrioventricular block, class IV heart failure * Iodine allergy * Renal dysfunction (creatinine above normal laboratory limits) * Symptomatic asthma * Women who are pregnant or breast-feeding

What they're measuring

Number of Flow-limiting Coronary Artery Stenosis on CT

Timeframe: Day 1 - Day of Scan

Association Between Stress Myocardial Blood Flow (MBF) on PET and Coronary Artery Stenosis on CCTA

Timeframe: Day 1 - Day of Scan

Trial details

NCT IDNCT05349084

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-07-18

Results submitted2024-07-30