HAIC Combined With Donafenib and Sintilimab for Unresectable ICC

Inclusion Criteria: * Unresectable or metastatic histologically or cytologically confirmed ICC * No previous systemic treatment or local anti-tumor treatment other than surgery (biliary drainage is allowed), admission was allowed for more than 6 months after the end of adjuvant therapy * Child-Pugh score ≤7 * Life expectancy ≥ 3 months * At least one measurable lesion as defined by Response Evaluation Criteria in Solid Tumors (RECIST)1.1 criteria * Eastern Cooperative Oncology Group(ECOG) performance status (PS) ≤ 1 * The functional indicators of important organs meet the following requirements: * Adequate blood count, liver-enzymes, and renal function: absolute neutrophil count ≥ 1.5\*10\^9 /L; platelet (PLT) ≥ 80 \*10\^9 /L; hemoglobin (HGB) ≥ 9.0 g/dL * Bilirubin ≤ 1.5 times upper limits of normal (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 5 times ULN * Serum creatinine ≤ 1.5 times ULN, and creatinine clearance ≥ 60 ml/min (calculated by Cockcroft-Gault formula) * International normalized ratio (INR) and activated partial thromboplastin time (APTT) ≤ 1.5 times ULN * Normal thyroid function, defined as thyroid stimulating hormone (TSH) within the normal range. If the baseline of TSH is outside the normal range, patients with normal total T3 (or FT3) and free tetraiodothyronine (FT4) can also be enrolled * The myocardial enzyme profile was within the normal range * For women who are not breastfeeding or pregnant, use contracept…