Monocyte Priming When Consuming a Western Diet (NCT05348395) | Clinical Trial Compass
CompletedNot Applicable
Monocyte Priming When Consuming a Western Diet
United States8 participantsStarted 2023-01-06
Plain-language summary
To determine the mechanism of monocyte priming in humans, the study team will conduct a complete feeding trial in normal weight and metabolically healthy human subjects (20-45 years of age) using a western diet (WD), characterized as being high-saturated fat, high-fructose, and high-calorie for 8 weeks.
Who can participate
Age range20 Years – 45 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 20-45
* Planning to be available for the entire study period
* Able to speak and read English
* Normal weight (body mass index 18.5-24.9 kg/m2)
* Able to eat the prescribed diet
* Non-smoker
Exclusion Criteria:
* Excessive alcohol consumption
* History of chronic cardiometabolic disease or major risk factor, including diabetes, hypertension, hyperlipidemia, heart disease
* History of prior surgical procedure for weight control or liposuction
* Use of weight loss medications in previous 6 months
* Recent self-reported weight change
* Severe pulmonary disease requiring supplemental oxygen
* Abnormal renal or liver function
* History of non-skin cancer in the past 5 years
* Regular use of medications (prescribed or over-the-counter) that affect blood pressure, lipids, glucose, inflammation, or body weight
* Works night shifts
* Exercise per week \> 420 minutes total for moderate activity or \> 210 minutes for vigorous activity
* Any medical or behavioral indication that would make participation unsafe based on the judgement of the study physician
* Pregnant or lactating women
* Known or discovered intolerances, allergies or difficulty consuming any of the foods included in the study diets
What they're measuring
1
Measurement of Mitogen-activated Protein Kinase Phosphate 1 (MKP-1) Activity
Timeframe: Baseline (experimental phase)
2
Measurement of Mitogen-activated Protein Kinase Phosphate 1 (MKP-1) Activity