Chlorophyllin Tablets for Urinary Bleeding Following Radiation Therapy for Cancers of Pelvic Organs

Inclusion Criteria: * Patients ≥ 18 years of age with a history of radiotherapy for pelvic malignancy in the past more than 3 months back. * Any grade of radiation-induced cystitis as per RTOG criteria (RTOG Grade 1-4 equivalent to CTCAE Grade 1-3). * Adequate liver function defined as ALT/ALT ≤ 3 times ULN and total bilirubin ≤ 2 times ULN. Elevated transaminases up to 5 times ULN is allowed in patients with liver metastasis. * Adequate renal function defined as creatine clearance ≥ 30 mL/min (By Cockcroft-Gault formula). Exclusion Criteria: * Known hypersensitivity or contraindications against sodium chlorophyllin. * Hemodynamically unstable patients not responding to initial resuscitation. * Patients with life-threatening hemorrhagic cystitis requiring urgent invasive intervention (CTCAE grade 4).